Rifamycin S, 8-Methyl-

CHF 150.00
In stock
AG-CN2-0337-M01010 mgCHF 150.00
AG-CN2-0337-M05050 mgCHF 600.00
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Product Details
Synonyms 8-Methylrifamycin S; 8-O-Methylrifamycin S; 1,​4-​Dideoxy-​1,​4-​dihydro-​8-​O-​methyl-​1,​4-​dioxo-rifamycin
Product Type Chemical
Properties
Formula

C38H47NO12

MW 709.8
CAS 42898-13-5
Source/Host Chemicals Semisynthetic.
Purity Chemicals ≥90% (HPLC)
Appearance Yellow to orange powder.
Solubility Soluble in DMSO, aqueous acetonitrile or ethanol.
Identity Determined by 1H-NMR and MS.
InChi Key CWRGYNMOWZQIMN-KSWODUNLSA-N
Smiles O=C1C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)=CC(C3=C4C(O[C@@]2(C)C4=O)=C(C)C(OC)=C31)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Ansamycin antibiotic.
  • Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
  • Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
  1. The constitution and configuration of rifamycins B, O, S and SV: W. Oppolzer & V. Prelog; Helv. Chim. Acta 56, 2287 (1973)
  2. Letter: Electronegative groups at C-3 of rifamycin S enhance its activity toward DNA-dependent RNA polymerase: M.F. Dampier & H.W. Whitlock; JACS 97, 6254 (1975)
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