Rifamycin M14

CHF 110.00
In stock
AG-CN2-0332-M01010 mgCHF 110.00
AG-CN2-0332-M05050 mgCHF 440.00
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Product Details
Synonyms Rifamide; NCI 143-418; NSC 143418; RF M-14; Rifampicin M/14; N,N-Diethylamide-rifamycin B; Rifomycin B diethylamide
Product Type Chemical


MW 810.9
CAS 2750-76-7
Source/Host Chemicals Semisynthetic.
Purity Chemicals ≥95% (HPLC)
Appearance Yellow to orange powder.
Solubility Soluble in DMSO, aqueous acetonitrile or ethanol.
Identity Determined by 1H-NMR and MS.
Smiles OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C=C(OCC(N(CC)CC)=O)C3=C4C(O[C@@]2(C)C4=O)=C(C)C(O)=C31
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Ansamycin antibiotic.
  • Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
  • Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
  1. In vitro bacteriological studies on rifamycin B diethylamide (rifamide): R. Pallanza, et al.; Arzneimittelforschung 15, 800 (1965)
  2. The inhibition of bacterial RNA synthesis by the rifamycin antibiotics: J.M. Wilhelm, et al.; Biochim. Biophys. Acta 166, 268 (1968)
  3. Rifamycins: A General View: S. Riva & L.G. Silvestri; Ann. Rev. Microbiol. 26, 199 (1972)
  4. Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
  5. Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
  6. Inhibition of poly(A) polymerase by rifamycin derivatives: S.T. Jacob & K.M. Rose; Nucl. Acids Res. 1, 1549 (1974)
  7. Structure-Activity Relationships and DNA Polymerases From Normal and Specificity of Inhibition of Leukemia Cells of Man and From Simian Sarcoma Virus by Rifamycin Derivatives: R.A. CiCioccio & B.I.S. Srivastava; J. Natl. Cancer Inst. 61, 1187 (1978)
  8. Comparison of antibacterial and antiimmune effects of certain rifamycins: J.E. Kasik & M. Monick; Antimicrob. Agents Chemother. 19, 134 (1981)
  9. In vitro activity of rifamycins alone and in combination with other antibiotics against Chlamydia trachomatis: R.B. Jones, et al.; Rev. Infect. Dis. 5, S556 (1983)
  10. QSAR Modeling of Antimycobacterial Activity and Activity Against Other Bacteria of 3-Formyl Rifamycin SV Derivatives: D. Dimov, et al.; Quant. Struct.-Act. Relat. 20, 298 (2001)
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