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AdipoGen Life Sciences
Thermorubin
110
CHF
CHF 110.00
In stock
AG-CN2-0339-M0011 mgCHF 110.00
AG-CN2-0339-M0055 mgCHF 380.00
AG-CN2-0339-M02525 mgCHF 1'140.00
| Product Details | |
|---|---|
| Synonyms | Thermorubin A; NSC105760 |
| Product Type | Chemical |
| Properties | |
| Formula |
C32H24O12 |
| MW | 600.5 |
| CAS | 37577-75-6 |
| Source/Host Chemicals | Isolated from Thermoactinomyces sp. |
| Purity Chemicals | ≥85% (HPLC) |
| Appearance | Red to violet powder. |
| Solubility | Soluble in DMSO, aqueous acetonitrile or ethanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | GGEDVBUCHDZLTH-MOSHPQCFSA-N |
| Smiles | O=C1OC(C(OC)=O)=CC2=C1C(O)=C(C(OC)=C(C(OC)=C(C(/C=C(O)/C3=C(O)C=CC=C3)=O)C(CC(O)=O)=C4)C4=C5)C5=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anthracene antibiotic.
- Antibacterial agent. Active against both Gram-positive and Gram-negative bacteria.
- Inhibits the initiation stage of bacterial protein synthesis by binding to the inter-subunit bridge B2a on the 70S ribosome.
- Does not inhibit DNA and RNA synthesis.
- Potent aldose reductase inhibitor.
Product References
- Structure of thermorubin A, the major orange-red antibiotic of Thermoactinomyces antibioticus: C.E. Moppett, et al.; JACS 94, 3269 (1972)
- The protein synthesis inhibitor thermorubin. 1. Nature of the thermorubin-ribosome complex: F. Lin & A. Wishnia; Biochem. 21, 477 (1982)
- The protein synthesis inhibitor thermorubin. 2. Mechanism of inhibition of initiation on Escherichia coli ribosomes: F. Lin & A. Wishnia; Biochem. 21, 484 (1982)
- Synthesis and antibacterial activity of some derivatives of the antibiotic thermorubin: B. Cavalleri, et al.; J. Antibiot. 38, 1752 (1985)
- Thermorubin and 2-hydroxyphenyl acetic acid, aldose reductase inhibitors: K. Hayashi, et al.; J. Antibiot. 48, 1345 (1995)
- The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome: D. Bulkley, et al.; J. Mol. Biol. 416, 571 (2012)
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