Erythroferrone (human) Matched Pair Detection Set

CHF 750.00
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AG-46B-0012-KI011 SetCHF 750.00
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Product Details
Synonyms CTRP15; Complement C1q Tumor Necrosis Factor-related Protein 15; Myonectin; FAM132B; ERFE
Product Type Kit
Application Set Quantitative ELISA

Detects human Erythroferrone [Myonectin; CTRP15] in serum, plasma and cell culture supernatant.

Crossreactivity Human

Contains sufficient materials to run ELISAs on 5 x 96-well plates.

Range 0.078 to 5ng/ml
Sample Type Cell Culture Supernatant
Assay Type Sandwich
Detection Type Colorimetric
Kit Contains

1 vial standard protein (100ng) (lyophilized) [STD]

1 vial coating antibody (120µl) [COAT]

1 vial detection antibody (60µl) [DET]

1 vial streptavidin-HRP (10µg) (lyophilized) [STREP]

Other Product Data

UniProt link Q4G0M1: Erythroferrone (human)

See our Erythroferrone Landing Page for important Information!

Accession Number Q4G0M1
Shipping and Handling
Shipping BLUE ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Erythroferrone (also called Myonectin, CTRP15 or Fam13B) is a member of CTRPs (C1q/TNF-related proteins), which are conserved paralogs of adiponectin containing collagen-like and globular C1q-like domains. Erythroferrone plays two different regulatory roles:

i) Erythroferrone (called Myonectin for this role) is a myokine abundantly expressed in skeletal muscle tissue, upregulated by voluntary exercise that is suppressed by fasting and induced by refeeding; it participates in the regulation of systemic lipid metabolism by promoting the clearance of nonesterified fatty acids (NEFA) from circulation. As a myokine, Erythroferrone/Myonectin acts as an endurance exercise-driven myokine which protects the heart from ischemic injury by reducing cardiomyocyte apoptosis and macrophage inflammatory response.

ii) Erythroferrone is produced by erythroblasts after bleeding or EPO treatment and acts on hepatocytes to suppress hepcidin expression, resulting in increased release of iron from cellular iron stores. Erythroferrone acts on hepcidin by inhibiting members of the BMP-5, BMP-6 and BMP-7 subgroup of BMPs. Erythroferrone functions as erythroid modulator of iron metabolism and hemoglobin synthesis.

Our Erythroferrone (human) Matched Pair Detection Set has been validated by the Swiss Laboratory for Doping Analyses in a recent publication reporting that our assay can sensitively detect the stimulation of erythropoiesis, including erythropoiesis stimulating agents (ESA, such as Erythropoietin) abuse and blood withdrawal. Erythroferrone is a biomarker for different types of anemia, for cardiology and potentially also for metabolic diseases. 

Product References
  1. Erythroferrone as a sensitive biomarker to detect stimulation of erythropoiesis: K. Ramirez Cuevas, et al.; Drug Test. Anal. (Epub ahead of print) (2019)
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