CD137 – CD137L Pathway

CD137 and CD137L Pathway CD137 (4-1BB; TNFRSF9) is an activating receptor binding to CD137L (4-1BBL; TNFSF9). Because CD137 is expressed on both natural killer (NK) cells and T cells, it can trigger both innate and adaptive immunity. After these cells have been activated by exposure to tumor antigen, CD137 signals stimulate them to reproduce and to generate antitumor activity. CD137 has been shown to play a critical role on T cells in the development of immune memory and the creation of a durable immune response. On lymphocytes, the presence of CD137 appears to be a marker for tumor reactivity. Activation of CD137 signaling can stimulate both cytotoxic T cell and NK cell activity.

LIT: 4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy: D.S. Vinay & B.S. Kwon; BMB Rep. 47, 122 (2014) • CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses: B. Dharmadhikari, et al.; Oncoimmunology 5, e1113367 (2015)

Biologically Active CD137 and CD137L Proteins

Product Name	PID	Source	Endotoxin	Species
CD137 (mouse):Fc (human) (rec.)	AG-40A-0025	HEK 293 cells	<0.1EU/µg	Mouse
CD137 (human) (rec.) (His)	CHI-HR-200CD137	E. coli	<0.1EU/µg	Human
CD137 (human):Fc (human) (rec.)	AG-40B-0060	HEK 293 cells	<0.01EU/µg	Human
CD137 (human):Fc (human) (rec.)	CHI-HF-210CD137	CHO cells	<0.06EU/µg	Human
CD137 (human):Fc (mouse) (rec.)	CHI-HF-211CD137	HEK 293 cells	<0.005EU/µg	Human
CD137L, Soluble (mouse) (rec.)	AG-40A-0020Y	HEK 293 cells	<0.01EU/µg	Mouse
CD137L, Soluble (human) (rec.)	AG-40A-0198T	HEK 293 cells	<0.06EU/µg	Human
Fc (human):CD137L, Soluble (human) (rec.)	AG-40B-0173	HEK 293 cells	<0.01EU/µg	Human
CD137L (human)-muCD8 Fusion Protein	ANC-503-020 All Labeled Variants	CHO cells	n.d.	Human

VALIDATED Antibodies for CD137 and CD137L Research

Product Name	PID	Isotype	Applications	Species
CD137 (human), mAb (4B4-1)	ANC-360-020 All Labeled Variants	Mouse IgG1κ	FACS, FUNC	Human, Monkey
CD137 (human), pAb	AG-25A-0018	Rabbit	FACS, WB	Human
CD137L (human), mAb (41B436)	AG-20A-0031	Mouse IgG1κ	FACS, ICC, WB	Human
CD137L (human), mAb (ANC5D6)	ANC-365-020 All Labeled Variants	Mouse IgG2aκ	FACS, WB	Human

Select Your Pathway of Interest & Discover High Quality Reagents

PD-1 [CD279] / PD-1L [CD274] Pathway	CTLA-4 [CD152] - CD80 - CD86 - CD28 Network
ICOS [CD278] / ICOSL [CD275] Pathway	LAG-3 [CD223] - MHC -TCR Pathway
TIM-3 / Galectin-9 Pathway	TIGIT - CD155 - CD112 - CD226 Network
CD137 [4-1BB] / CD137L [4-1BBL] Pathway	OX40 [CD134] / OX40L [CD252] Pathway
GITR [CD357] / GITRL Pathway	HVEM [CD270] - BTLA [CD272] - LIGHT -CD160 Network
CD40 / CD40L [CD154] Pathway	New B7 Family Members - B7-H3 [CD276], B7-H4, B7-H5 [VISTA], B7-H6
Butyrophilin-like Proteins & Other Immune Checkpoint Proteins	Back to Immune Checkpoint Overview