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GITR – GITRL Pathway
Glucocorticoid-induced TNFR-related protein (GITR; CD357; TNFRSF18) is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL (TNFSF18). Once exposure to tumor antigen activates a T cell, the number of GITR receptors on its surface increases. On the activated T cell, GITR acts as a co-stimulatory receptor, meaning that it is a receptor whose signaling enhances cell reproduction and the generation of cancer-killing activity. Activation of GITR signaling can also help to enhance immunity through the activation of cytotoxic T cells and inhibition of Treg activity.
LIT: Modulation of GITR for cancer immunotherapy: D.A. Schaer, et al.; Curr. Opin. Immunol. 24, 217 (2012) | Rationale for anti-GITR cancer immunotherapy: D.A. Knee, et al.; Eur. J. Cancer 67, 1 (2016)
Biologically Active GITR and GITRL Proteins
| Product Name | PID | Source | Endotoxin | Species |
| GITR (mouse):Fc (human) (rec.) | AG-40B-0002 | HEK 293 cells | <0.01EU/µg | Mouse |
| GITR (human):Fc (human) (rec.) | AG-40B-0028 | HEK 293 cells | <0.01EU/µg | Human |
| GITRL, Soluble (mouse) (rec.) | AG-40A-0008 | HEK 293 cells | <0.1EU/µg | Mouse |
| GITRL, Soluble (human) (rec.) | CHI-AG-40A-0019 | HEK 293 cells | <0.06EU/µg | Human |
| GITRL, Soluble (human) (rec.) (His) | AG-40A-0024T | HEK 293 cells | <0.06EU/µg | Human |
VALIDATED Antibodies for GITR and GITRL Research
| Product Name | PID | Isotype | Applications | Species |
| GITR (human), mAb (ANC7D6) |
ANC-268-020 |
Mouse IgMκ | FACS | Human |
| GITR (human), mAb (ANC5E3) |
ANC-368-020 |
Mouse IgG3κ | FACS | Human |
| GITR (human), mAb (AIT 158D) | AG-20A-0017 | Rat IgG2aκ | FACS | Human |
| GITR (human), pAb | AG-25A-0017 | Rat | FACS | Human |
| GITRL (human), pAb | AG-25A-0023 | Rabbit | IHC, WB | Human |