ER 172594-06 hydrobromide

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SYN-3002-M0011 mgCHF 277.00
SYN-3002-M0055 mgCHF 653.00
SYN-3002-M01010 mgCHF 1'015.00
SYN-3002-M05050 mgINQ
SYN-3002-M100100 mgINQ
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Product Details
Synonyms Atopaxar hydrobromide; ER-172594-06; E5555
Product Type Chemical
Formula C29H39BrFN3O5 . HBr
MW 608.5 . 80.9
CAS 474550-69-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: N/A | Kinase Group: N/A | Substrate: N/A
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031µM, respectively.
Product References
  1. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease: V.L. Serebruany, et al.; Thromb. Haemost. 102, 111 (2009)
  2. Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease: S. Goto, et al.; Eur. Heart J. 31, 2601 (2010)
  3. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs: M. Kogushi, et al.; Eur. J. Pharmacol. 657, 131 (2011)
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