OX40 – OX40L Pathway

OX40 (CD134; TNFRSF4) is an activating receptor expressed on the surface of activated cytotoxic T cells and regulatory T cells (Tregs). OX40 plays a dual role in the immune response, both activating and amplifying T cell responses. On cytotoxic T cells, OX40 binds to its ligand OX40L (CD252; TNFSF4), resulting in stimulatory signals that promote T cell reproduction, function and survival. OX40/OX40L signaling blocks the ability of Tregs to suppress T cells and reduces Treg generation. By inhibiting the immunosuppressive effect of Tregs and limiting their population, OX40 further amplifies the impact of T cell activation. The dual effects of OX40 help to create a tumor microenvironment that is more favorable to the antitumor immune response.

LIT: OX40: Structure and function - What questions remain? J. Willoughby, et al.; Mol. Immunol. 83, 13 (2017) • The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy: S.L. Buchan, et al.; Blood 131, 39 (2018)

Biologically Active OX40 and OX40L Proteins  

VALIDATED Antibodies for OX40 and OX40L Research

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