Manufacturer of Products for Advanced Inflammation, Immune Response & Immunometabolic Research

Our New Website is LIVECaspase-1 p20 mAb (Casper-1)ELISA KitsmBaff Blocking mAb (Sandy-2)ProgranulinsNLRP3 mab Cryo-2CD40 Blocking mAb (FGK45)IL-36gamma ELISA KitRare Natural ProductsAsprosinSouthBayBio

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Powerful Effector of TetR & revTetR Systems
Anhydrotetracycline . HCl

Unique Tubulin-Modification Specific Antibody
anti-Tubulin (glycylated), pAb (Gly-pep1)

Detection of a New Fasting-induced Protein
Asprosin (human) Matched Pair Detection Set

HRP Substrate for Tyramide Signal Amplification
Biotinyl tyramide

Potent Mitochondria-dependent Apoptosis Inducer

Potent Notch Ligand with Enhanced Activity 
DLL4 (human):Fc (human) (rec.) (highly active mutant)

Tumor-specific Pyruvate Kinase M2 Inhibitor 

UNIQUE - Detects Monomeric & Dimeric IL-37 
IL-37 (human) ELISA Kit

Potent & Irreversible 20S Proteasome Inhibitor
Salinosporamide A

DYRK1 Inhibitors 
AnnH31 / AnnH75

New Postsynaptic Activity & Plasticity Marker
anti-PSD-95 (palmitoylated), mAb (rec.) (PF11)

High Activity OX40L Multimer Construct
Fc (human):OX40L, Soluble (human) (rec.)

Biologically Active TIM-3 Ligand 
Galectin-9 (human):Fc (human) (rec.)

Potent Mitochondrial Complex II Inhibitor 
Atpenin A5

NEW Potent CD137L Fusion Protein 
Fc (human):CD137L, Soluble (human) (rec.)

Rare Antitumor Antibiotic - Available from Stock! 

NEW Fasting-induced Protein Hormone 
Asprosin (human) (rec.) (His)

Unique Antibody to Deplete B Cells In Vivo 
anti-BAFF (mouse), mAb (blocking) (Sandy-2)

Potent & Selective Gαq Family Inhibitor 

Alzheimer Inducing Agent 

IL-36γ - Proinflammatory Cytokine 
anti-IL-36γ (human), mAb (Jussy-1)

NEW Factor in Inflammatory Bowel Disease 

Inhibitor of CDK5/p25 and GSK-3β 

CK2 Inhibitor & Thermogenesis Inducer 
CX-4945 . hydrochloride

Specific Biomarker for Psoriasis 
IL-36γ (human) ELISA Kit

NEW Immune Checkpoint Receptor 
CD112R (mouse):Fc (human) (rec.)

Potent pan-Akt (1/2/3) Inhibitor 

NEW Anticancer Compound 
Jak/Src Inhibitor 1 . hydrochloride

Potential Virulence Factor 
(-)-Mitorubrinic acid

Potent Inhibitor of mPGES-1

NEW Cinnamtannin B-1, Higher Purity >96% HPLC 
Cinnamtannin B-1

Potent Water Soluble JAK1 & JAK2 Inhibitor 
Ruxolitinib . phosphate salt

Biomarker for Airway Inflammation 
anti-Periostin, mAb (Stiny-1)

Lead Compound for DYRK1A Inhibitor Development 

Significant Marker for Malignancy 
Fibronectin (EDA), mAb (blocking) (IST-9) (preserv. free)

Newly Released Protein – BULK Available 
IL-38 (aa 20-152) (human) (rec.) (His)

Potent & Selective 11β-HSD1 Inhibitor 

Cell Death Inducer in Colorectal Cancer 
Lewisy/b hapten (human), mAb (SC104) (preservative free)

Nampt/Visfatin Inhibitor – BULK Available 

Cell Permeable, Potent & Selective FABP4 Inhibitor 

Endogenous Human ST2 Detection by FACS 
anti-ST2 (human), pAbs

New Potent Leptin Sensitizer 
Withaferin A

Innate Immune Sensor of Influenza A Virus 
anti-ZBP1, mAb (Zippy-1)

Tingling-inducing Agent - BULK Available 

New Activator of NLRP3  

Newly Described NLRP3 Inhibitor 
Prostaglandin E2 (PGE2)

Regulator of Adipose Tissue Thermogenesis 
Slit2 (C fragment) (human) (rec.)

Highly Active IL-33 Mutant Protein 
IL-33 (oxidation resistant) (human) (rec.) (His)

Potent and Selective PDE10A Inhibitor 

Potent Activators of TRPV3 
Incensol, Incensol acetate & Serratol

NEW Toll-Like Receptor Family Antibodies 
TLR2 - TLR10 Monoclonal Antibodies

Unique mouse LRP5/6 mAb for FACS 
anti-LRP5/6, mAb (rec.) (Heldy-1-4)

Potent & Selective GAPDH Inhibitor 
Heptelidic acid

Potent, Selective & Competitive Cell Permeable Rasfarnesyltransferase Inhibitor 
Manumycin A & related Products

Agonistic LTβR Monoclonal Antibodies 
anti-LTβR (mouse), mAbs - Clones 3C8 & 4H8WH2

Potent BTLA-blocking Antibody - Available again! 
anti-BTLA (human), mAb (6F4)

AhR Agonist - Increases ILC3 in Gut Microbiota 

Brown Adipose Tissue (BAT) Activator 

TRAIL-Rs – Important Cancer Regulators 
IHC and FACS competent TRAIL-Rs antibodies

Apaf-1 – Key Apoptosome Complex Factor 
Validated and specific Apaf-1 antibodies

Specific β-cell Proliferation Promoter 
GW311616A . hydrochloride

NEW Natural Anticancer Compounds 
Fridamycin A, B & Violacein

New Marker for Cardiology 
Nampt (Visfatin/PBEF) ELISA Kits

Unique Collagen Matrix Markers for ICC 
anti-Collagen Type 1 (3/4 fragment), pAbs

Inhibitor of FtsZ GTPase Activity 

Actin Polymerization Inhibitors in vitro and in vivo 
Latrunculin A+B

Selective Protease Inhibitors - BULK Available
Leupeptin, Pepstatin, Amastatin, Antipain...

A Multifunctional Adipokine Biomarker 
Nampt (Visfatin/PBEF) ELISA Kits

Exercise-induced Myokine Detection 
Irisin Competitive ELISA Kit

Potent LIM Kinase Inhibitor

Essential Axon Survival Factor – BULK available
NMNAT2 (human) (rec.) (His)

Orally Bioavailable Potent Inhibitor of JAK1 and JAK2

Specific SREBP Inhibitor - BULK available

Highly Active Untagged Proteins
IL-36α, IL-36β, IL-36γ, IL-36Ra

Rapid Apoptosis Inducer

Ionophore Antibiotics
Enniatins A/A1/B/B1

Potent Inhibitor of Human 5-lipoxygenase
Myxochelin A

For Enzymatic Assays & Inhibitor Screenings
IDO1 (human) Enzyme+Inhibitor Set

Potent Triazole IDO1 Inhibitor

Inhibitor of PVR/CD155 Ligand
TIGIT (human):Fc (human)

New Negative Checkpoint Regulator
VISTA [B7-H5]: Fc Proteins

High Sensitive Asthma Biomarker Detection Kit
Periostin (human) ELISA Kit

Now Available - Produced in CHO Cells
Periostin (human) (rec.)

Potent Cell Permeable JAK3 Inhibitor

Potent Na+/K+-ATPase Inhibitor

TurboELISA™ Kit - Results in less than 1 hour
Zinc-α-2-glycoprotein (human) TurboELISA Kit

Potent F-actin Modulators
Cucurbitacins B & E

Progranulin - Bulk Available
Recombinant human, mouse or rat Progranulin

Potent and Highly Selective BTK Inhibitor

Inflammasome Inhibitor for In Vivo Studies
MCC950 . sodium salt - BULK available

Unique - Produced in Mammalian Cells
Resistin (human) (rec.)

Highly Active IDO1 Enzyme for Inhibitor Screenings
IDO (human) (rec.) (His)

New UCP1-dependent Thermogenesis Inducer
CK2 Inhibitor 10

Biologically Active Cytokines
Human & Mouse IL-35

New Potent HDAC6 Inhibitors
Nexturastat B, Tubastatin A ...

Selective cell permeable MALT1 Inhibitor

Potent δ-Opioid Receptor Agonist - Bulk Available

New Biomarker for Plasma Triglyceride Levels
anti-Betatrophin (human), pAb (IN108)

New Specific IL-38 Monoclonal Antibody
anti-IL-38, mAb (Nhat-1)

Unique Antibody for Metabolic Research
anti-MPC-2, mAb (JCM-1)

Antibiotic & Anti-inflammatory Natural Products

Tumor Suppressor & Anti-Inflammatory Protein - Bulk Available
CD137L, Soluble (mouse) (rec.)

Important Metabolism and Energy Regulator
Propionyl-L-carnitine . hydrochloride

Available Again - Also Bulk Quantity
BTLA (human), mAb (6F4)

Frequently cited Standard Apoptosis mAbs
anti-FLIP & anti-Caspase-8

Potent CDK1 / Cyclin B Inhibitor - Bulk Available

GPVI Receptor Agonist for Platelet Receptor Studies

Functional Antibodies for in vivo Studies
anti-LTβR (mouse), mAbs

Potent and Selective CSF-1R Inhibitor

New Skin Inflammation Antibodies
IL-36β (human)

Adipocyte Differentiation Inducer
IL-33 (mouse), mAb (rec.) (blocking) (Bondy-1-1)

Potent iNKT Stimulators
α-Galactosylceramide & Analogs

Potent & Fast Acting Antibiotic
Puromycin . dihydrochloride

New Inflammation Detection Set
IL-38 (human) Matched Pair Detection Set

New Skin Inflammation Detection Set
IL-36β (human) Matched Pair Detection Set

Potent Anti-inflammatory & Antidiabetic Agents
Amorfrutin A & B

Potent Multimeric TNF-α Proteins
High Activity TNF-α Proteins

Specific Antiviral Signaling Antibodies
NS3, NS5B, GPx8 Specific Antibodies

Potent Anti-Malaria Compound - BULK available

Natural Inflammasome Inhibitors

Netrin-1 BULK Available
Biological Active Netrin-1 Proteins

Ectodomain Shedding Protease Blocking Antibody
anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12))

Anti-Diabetic & NLRP3 Inflammasome Inhibitor

Anti-Obesity Agent & Potent Leptin Sensitizer

Biologically Active DLL4 Notch Ligand
DLL4 (human):Fc (human) (rec.)

Biologically Active DLK1 Notch Ligand
DLK1 (human):Fc (human) (rec.)

Novel Inhibitor of Aurora A Kinase
Tripolin B

Anticancer and Trypanocidal Compound

Specific Anti-Obesity Adipokine ZAG Detection
Zinc-α-2-glycoprotein (human) Matched Pair Detection Set

A Novel Hormone Regulating Metabolism
CTHRC1 (mouse) (rec.)

Potent and Selective NLRP3 Inflammasome Inhibitor
MCC950 . sodium salt

Potent Neurotoxin Available from Stock

Standard FLIP Antibodies for Cell Death Research
anti-FLIP (human), mAb (NF6)
anti-FLIP, mAb (Dave-2)

Potent PD-1 & PDL-2 Immune Checkpoint Proteins
Human & Mouse Fc-Fusion Proteins – BULK Available

NF-kB p65 Suppressor

Cell Permeable MKLP-2 Inhibitor

New Potent Mitochondria-Derived AMPK Activator

Potent Apoptosis Inducing Fas Antibody
anti-Fas (human), mAb (APO-1-3) (preservative free)

HIGH PURITY Thapsigargin - BULK available
Thapsigargin (high purity)

Novel Type of RNA Guanylyltransferase Inhibitor
Mycophenolic acid

C15 - Standard Human-specific Caspase-8 Antibody
anti-Caspase-8 (human) mAb (C15)

Potent B7-H4 Immune Checkpoint Proteins
Mouse Fc-Fusion Proteins – BULK Available

Potent Inducer of Actin Polymerization

Potent Immunosuppressant

Immune Checkpoint Protein Flyer
Broad Panel of Proteins for In Vivo Studies

Potent CTLA-4 Immune Checkpoint Proteins
Human & Mouse Fc-Fusion Proteins – BULK Available

Photosensitizing Anticancer Agent

Cell Permeable Microtubule Inhibitor

IL-36 – New Tools for Skin & Dendritic Cell Research
Antibodies, Proteins & Detection Sets

Unique Epidermal Skin Markers
Cornulin, Repetin, SPRR2, SPRR3 Antibodies

Anticoccidial Antibiotic

Potent Anti-Tuberculosis Antibiotic
Actinomycin X2

Active Adipogenesis Inhibitor
Jagged-1 (mouse):Fc (human) (rec.)

Novel Cold-Induced Adipokine
Neuregulin-4 (human) (rec.)

Live Imaging Acidotropic Fluorescent Dye

Selective Cyclooxygenase-2 (COX-2) Inhibitor

GPx8 - Cellular Substrate of HCV NS3-4A Protease
GPx8 (human), pAb (IN103)

Potent Inhibitor of Actin Polymerization
Cytochalasin H

Unique Anaphase Promoting Complex Inhibitor

Potent mouse Angiopoietin-2 Blocking Antibody
Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1)

Sterile TLR4 Agonist Array
MPLA | Kdo2 | Lipid A | LPS

PI3K Class I, MKK3/6 & MKK4 Inhibitor

Mitochondrial Respiration Inhibitor

NLRC3 - Negative Regulator of Innate Immunity
NLRC3 (mouse), mAb (Eowyn-1)

Non-cytotoxic Melanogenesis Inhibitor
Aspochalasin I

Hypersensitive Autoimmune Disease Biomarker
BAFF (human) ELISA Kit (hypersensitive)

BULK - Now Available from Stock!
Pellitorine & Indolactam V

Fungal Anticancer Compounds from BioViotica
Cephalochromin & Trypacidin

Unique mAPRIL Blocking Antibody
APRIL (mouse), mAb (rec.) (blocking) (Apry-1-3)

Standard Apoptosis Antibodies
Apaf-1 | BimL | Bmf | Caspase-2/-8/-12

Pan-PI3K Inhibitor

Inhibitor of Isocitrate Lyase in Bacteria
Itaconic acid


BAFF and APRIL Inhibitors to study Mice Autoimmunity

The TNF superfamily ligands, BAFF and APRIL, are involved in the pathogenesis of a number of autoimmune diseases by regulating plasma cell survival. AdipoGen Life Sciences provides unique antibodies to study autoimmune diseases in mice by blockade of mouse BAFF or APRIL, such as anti-BAFF (mouse), mAb (blocking) (Sandy-2) or anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1).

In a recent study, Haselmayer et al., tested several inhibitors of BAFF or APRIL in a model of mouse autoimmune disease (SLE) to confirm that inhibition of mouse BAFF and APRIL by the receptor TACI-Fc is more efficient than inhibition of BAFF alone or APRIL alone on long-lived plasma cell survival. To block mouse APRIL in this study, anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1) (AG-27B-0001PF) from Adipogen was injected in C57BL/6 mice.

LIT: A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells: P. Haselmayer, et al.; Eur. J. Immunol. 47, 1075 (2017)

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© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.