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Innovative Research Reagents for Inflammation & Immune Responses
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Latest Product Highlights ArchiveNew Neuroprotective Agent Reducing Intracellular Oxidative Stress
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News & Press ReleasesAbcalis and AdipoGen Life Sciences Partner on Distributing Animal-free Recombinant Monoclonal and Multiclonal Antibodies on the Life Science Research Market The Innate Sensor ZBP1 is inhibited by ADAR1 Four studies published recently in the journals Cell Reports and Nature identify the IFN-induced protein ZBP1, the only other protein in mammals known to harbor Zα domains binding to Z-dsRNA, as a key effector of autoinflammatory pathology induced by mutations of the Z-DNA-binding domain of ADAR1. The findings indicate that ADAR1 is a negative regulator of sterile ZBP1 activation. |
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